Dose-response curves for erythrocyte protoporphyrin vs blood lead: effect of iron status
Journal Article
·
· Environ. Res.; (United States)
An increase in erythrocyte protoporphyrin (EP) is one of the most useful indicators of adverse biological response to lead exposure. A nonlinear mathematical model relating EP to blood lead concentration (PbB) was fitted to data in a sample of 1677 US children (ages 2-6 years) in the Second National Health and Nutrition Examination Survey (NHANES II). Iron status was defined by percentage transferrin saturation (PTS). The dose-response curves for EP vs PbB increased systematically with decreasing PTS, largely due to decrease of a parameter proportional to red cell lead-holding capacity with decreasing PTS.
- Research Organization:
- Environmental Protection Agency, Research, Triangle Park, NC
- OSTI ID:
- 5516788
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 44:2; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Association of erythrocyte protoporphyrin with blood lead level and iron status in the second National Health and Nutrition Examination Survey, 1976-1980
Dose-effect and dose-response relationships of blood lead to erythrocytic protoporphyrin in young children
Assessing the risks to young children of three effects associated with elevated blood-lead levels
Journal Article
·
Wed Oct 01 00:00:00 EDT 1986
· Environ. Res.; (United States)
·
OSTI ID:5115338
Dose-effect and dose-response relationships of blood lead to erythrocytic protoporphyrin in young children
Conference
·
Tue Oct 01 00:00:00 EDT 1985
· Environ. Res.; (United States)
·
OSTI ID:6079930
Assessing the risks to young children of three effects associated with elevated blood-lead levels
Technical Report
·
Sun Nov 30 23:00:00 EST 1986
·
OSTI ID:6956462
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
BIOLOGICAL MARKERS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD CHEMISTRY
BODY FLUIDS
CARBOXYLIC ACIDS
CHILDREN
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ERYTHROCYTES
GLOBULINS
GLOBULINS-BETA
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IRON
LEAD
MATERIALS
MATHEMATICAL MODELS
METALLOPROTEINS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
PROTOPORPHYRINS
SCREENING
TOXICITY
TRANSFERRIN
TRANSITION ELEMENTS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
BIOLOGICAL MARKERS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD CHEMISTRY
BODY FLUIDS
CARBOXYLIC ACIDS
CHILDREN
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ERYTHROCYTES
GLOBULINS
GLOBULINS-BETA
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IRON
LEAD
MATERIALS
MATHEMATICAL MODELS
METALLOPROTEINS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
PROTOPORPHYRINS
SCREENING
TOXICITY
TRANSFERRIN
TRANSITION ELEMENTS