Metabolism of manganese in calves as affected by dietary manganese and intravenous or duodenal manganese-54 dosing

Journal Article · Thu Oct 01 04:00:00 EDT 1987 · J. Dairy Sci.; (United States)

DOI:https://doi.org/10.3168/jds.S0022-0302(87)80257-6· OSTI ID:5516696

Miller, W J; Stake, P E; Neathery, M W; Gentry, R P; Blackmon, D M

Fifteen intact male Holstein calves averaging 101 d of age were utilized to determine the effects of dietary Mn concentration and routes of administration on its metabolism. They were fed a practical grain diet containing 23 ppm Mn with 0, 100, or 1000 ppm supplemental Mn (MnSO/sub 4/.H/sub 2/O) for 7 d prior to intravenous or duodenal dosing with /sup 54/Mn. Animals were killed 4 h later. With added Mn there was a significant decrease in /sup 54/Mn content of some small intestine parts. However, in most tissue, including organs, bones, intestinal tract tissues, and blood, added Mn did not have a significant effect on /sup 54/Mn concentrations. Concentrations of /sup 54/Mn in tissues, except in small intestine, were far higher following intravenous dosing than with duodenal dosing. This further confirms that absorption of Mn is very low. Dosing method had a sizable effect on the relative amounts of /sup 54/Mn in different tissues. This suggests that intravenously administered Mn, at least initially, is not metabolized in the same way as that absorbed. In most tissues, unlabeled Mn was not affected greatly by supplemental Mn. This is in contrast to earlier results with very young calves and indicates that Mn metabolism changes sharply before 3 to 4 mo of calf age.

• Research Organization: Univ. of Georgia, Athens
• OSTI ID: 5516696
• Journal Information: J. Dairy Sci.; (United States), Journal Name: J. Dairy Sci.; (United States) Vol. 70:10; ISSN JDSCA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
CALVES
CATTLE
DAYS LIVING RADIOISOTOPES
DIET
DISTRIBUTION
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MANGANESE
MANGANESE 54
MANGANESE ISOTOPES
METABOLISM
METALS
NUCLEI
ODD-ODD NUCLEI
RADIOISOTOPES
RUMINANTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES