Effect of whole-body irradiation of mice on the number of background plaque-forming cells
Mice were exposed in whole-body fashion to several doses of radiation and killed at various times thereafter for a determination of the number of background plaque-forming cells (PFCs) as assayed on either sheep erythrocytes or bromelain-treated autologous mouse erythrocytes. Increased numbers of both types of PFC were found in the irradiated groups. These increases were dependent on radiation dose and time after exposure. They did not appear to be caused by a disruption of normal lymphocyte traffic or a switch in immunoglobulin isotype. An increased number of PFCs on bromelain-treated mouse RBCs but not on sheep RBCs were found in irradiated congenitally athymic nude mice. On the basis of this and related observations, background PFCs on bromelain-treated mouse RBCs and on sheep RBCs appear to fall under different forms of homeostatic control.
- Research Organization:
- Department of Pathology, University of New Mexico School of Medicine, Albuquerque
- OSTI ID:
- 5514349
- Journal Information:
- Arch. Pathol. Lab. Med.; (United States), Vol. 107:8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
PLAQUE FORMATION
BIOLOGICAL RADIATION EFFECTS
ANTIBODY FORMATION
BONE MARROW
ERYTHROCYTES
MICE
WHOLE-BODY IRRADIATION
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IRRADIATION
MAMMALS
MATERIALS
ORGANS
RADIATION EFFECTS
RODENTS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals