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Enzymes of DNA synthesis in rat bone marrow during chronic exposure to radiation. [. gamma. rays]

Journal Article · · Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5512231
The activity of enzymes of DNA synthesis in bone marrow during long-term exposure to radiation in a dosage of 25 R, which leads to formation of a chronic radiation lesion was investigated. Experiments were conducted on male Wistar rats which were exposed to radiation daily from a cesium ..gamma..-source in a dosage of 25 R at a dose rate of 10.3 R/min. The activity of enzymes of phosphorylation of thmydine and thymidylic acid to TTP and DNA polymerase was measured. For the first 11 experimental days, kinase activity was 1.5 times higher than the control levels. At subsequent times, there was a decrease in activity of these enzymes to the normal level. These changes in DNA polymerase activity were not statistically significant in the bone marrow of irradiated animals, as compared to the control, throughout the irradiation period. No perceptible changes in number of myelokaryocytes were demonstrable in bone marrow during exposure of the rats to radiation under the same conditions. Thus, this study demonstrated that there was little change in activity of the enzymes of DNA synthesis in bone marrow cells in the course of chronic exposure of rats to radiation (daily dose 25 R). At the same time, with a lower daily dose (25), statistically reliable changes in cell composition of bone marrow tissue were also absent. (ERB)
OSTI ID:
5512231
Journal Information:
Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:3; ISSN RADBA
Country of Publication:
United States
Language:
English

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Related Subjects

560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BONE MARROW CELLS
CESIUM 137
CESIUM ISOTOPES
CHRONIC EXPOSURE
CHRONIC IRRADIATION
CONNECTIVE TISSUE CELLS
CUMULATIVE RADIATION EFFECTS
DATA
DATA FORMS
DNA REPLICATION
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GAMMA RADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOTOPES
LOW DOSE IRRADIATION
MAMMALS
NUCLEI
NUCLEIC ACID REPLICATION
NUMERICAL DATA
ODD-EVEN NUCLEI
PHOSPHOTRANSFERASES
POLYMERASES
RADIATIONS
RADIOISOTOPES
RATS
RODENTS
SOMATIC CELLS
TRANSFERASES
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES