Information profiles on potential occupational hazards: Organic anhydrides. Draft report (Second)

Technical Report · Sun Jan 31 23:00:00 EST 1982

OSTI ID:5512134

Information profiles are presented on these organic anhydrides: acetic anhydride, butyric anhydride, citraconic anhydride, dodecenylsuccinic anhydride, isobutyric anhydride, maleic anhydride, phthalic anhydride, propionic anhydride, pyromellitic dianhydride, succinic anhydride, tetrahydrophthalic anhydride, and trimellitic anhydride. The organic anhydrides appear to be moderately toxic with median lethal dose levels for rats ranging from 697 to 2600 mg/kg. The maleic, phthalic, acetic, and trimellitic anhydrides appear to be the most acutely toxic of the group discussed. All were irritants to the skin, eyes, and respiratory tract. Injection site tumors have occurred following administration of succinic and maleic anhydrides. Limited evidence suggests teratogenic potentials for acetic, maleic, phthalic, and succinic anhydrides.

• Research Organization: Syracuse Research Corp., NY (USA). Center for Chemical Hazard Assessment
• OSTI ID: 5512134
• Report Number(s): PB-89-216618/XAB; SRC-TR--81-635
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANHYDRIDES
BIOLOGICAL EFFECTS
CHEMICAL ANALYSIS
CONTROL EQUIPMENT
EQUIPMENT
INDUSTRIAL MEDICINE
MATERIALS
MEDICINE
OCCUPATIONAL SAFETY
ORGANIC COMPOUNDS
PRODUCTION
SAFETY
TOXIC MATERIALS
TOXICITY