Deuterated methoxyflurane anesthesia and renal function in Fischer 344 rats
Inorganic fluoride (F-) production and renal function were assessed in six groups of Fischer 344 rats administered either methoxyflurane (MOF) or deuterated methoxyflurane (d4-MOF). One untreated and one phenobarbital (PB)-treated group were exposed for two hours to either air, 0.5 per cent (V/v) MOF, or 0.5 per cent (v/v) d4-MOF. Serum and urinary F- and serum urea nitrogen and creatinine were measured. Urine volume and urinary F- excretion were only slightly greater among MOF than among d4-MOF exposed animals. Pretreatment with PB, however, greatly enhanced F- production in MOF-exposed animals leading to marked renal impairment but only slightly enhanced F- production in d4-MOF animals leading to mild renal impairment. Thus, only in PB-pretreated animals could a biologically significant difference in nephrotoxicity be demonstrated for MOF and d4-MOF.
- Research Organization:
- Stanford University School of Medicine, Veterans Administration Medical Center, Palo Alto
- OSTI ID:
- 5510629
- Journal Information:
- Anesthesiology; (United States), Vol. 56:3
- Country of Publication:
- United States
- Language:
- English
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560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)