Antimutagenic effects in humans

Mendelsohn, Mortimer L.

doi:10.1016/0027-5107(92)90070-i

Antimutagenic effects in humans

Conference · Thu Mar 20 23:00:00 EST 2003 · Mutation Research

DOI:https://doi.org/10.1016/0027-5107(92)90070-i· OSTI ID:5509516

Mendelsohn, Mortimer L. ^[1]

Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

The application of antimutagenicity studies to human somatic mutation is discussed, with emphasis on the potential for future studies. Five assay-gene combinations are now available for measuring human somatic mutation in lymphocytes and erythrocytes. Results with these combinations have defined the human background levels, and show clear responses of mutant frequency to a variety of mutagens. The testing of antimutagenic effects of background frequencies is feasible, but has not yet been done. The major uncertainty in such studies is the unknown age of mutant cells in the background, since only the newly forming mutants are potentially susceptible to most antimutagenic treatments. Intervention studies in the face of active mutagenicity and the use of other genotoxicity endpoints, such as chromosome aberrations, micronuclei and DNA adducts, are considered briefly.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: W-7405-ENG-48

OSTI ID:: 5509516

Report Number(s):: UCRL-JC--106806; CONF-9105234--1; ON: DE91015687

Journal Information:: Mutation Research, Journal Name: Mutation Research Journal Issue: 2 Vol. 267; ISSN 0027-5107

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

References (23)

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550200 -- Biochemistry
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ADDUCTS
ANIMALS
BIOASSAY
BIOLOGICAL PATHWAYS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CYTOLOGICAL TECHNIQUES
DNA ADDUCTS
INHIBITION
MAMMALS
MAN
MUTAGENESIS
MUTATION FREQUENCY
MUTATIONS
PRIMATES
SOMATIC MUTATIONS
SPONTANEOUS MUTATIONS
VERTEBRATES

Antimutagenic effects in humans

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References (23)

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