No-carrier-added (/sup 18/F)-N-methylspiroperidol

Patent · Fri Oct 04 00:00:00 EDT 1985

OSTI ID:5507337

Shiue, C Y; Fowler, J S; Wolf, A P

The present invention is directed to the synthesis of a radioligand, labeled with a positron emitting radionuclide which is suitable for dynamic studies in humans using positron emission transaxial tomography. No-carrier-added (NCA) (/sup 18/F)-N-methylspiroperiodl is prepared from four different sustrates: p-nitrobenzonitrile, cyclopropyl p-nitrophenyl ketone, p-cyclopropanoyl-N,N,N-trimethylanilinium iodide and p-cyclopropanoyl-N,N,N-trimethylanilinium perchlorate. The process for the production of NCA (/sup 18/F)-N-methylspiroperidol is a nucleophilic aromatic substitution reaction. Furthermore, the compound of this invention is shown to be effective as a new drug of choice for in vivo examination of dopamine binding sites in a human brain. In particular, this drug is primarily useful in the noninvasive technique of positron emission transaxial tomography (PETT).

• Research Organization: Brookhaven National Laboratory (BNL), Upton, NY (United States)
• DOE Contract Number: AC02-76CH00016
• Assignee: Dept. of Energy
• Application Number: ON: DE86013761
• OSTI ID: 5507337
• Resource Relation: Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
DIAGNOSTIC USES
FLUORINE 18
LIGANDS
POSITRON COMPUTED TOMOGRAPHY
TRANQUILIZERS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CENTRAL NERVOUS SYSTEM AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
NUCLEI
ODD-ODD NUCLEI
PSYCHOTROPIC DRUGS
RADIOISOTOPES
SYNTHESIS
TOMOGRAPHY
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics