Role of tachykinins in ozone-induced acute lung injury in guinea pigs

Journal Article · Wed Sep 01 04:00:00 EDT 1993 · Journal of Applied Physiology (1985); (United States)

OSTI ID:5506368

Tepper, J S; Costa, D L; Fitzgerald, S; Doerfler, D L; Bromberg, P A ^[1]

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1. ManTech Environmental Technology, Inc., Research Triangle Park, NC (United States)

To examine the hypothesis that the acute reversible changes caused by ozone (O3) exposure are mediated by tachykinin release, guinea pigs were depleted of tachykinins by use of repeated capsaicin (CAP) injections before O3 exposure in an attempt to prevent O3-induced functional changes. Unexpectedly, CAP pretreatment caused divergent results in the functional responses to O3. Ventilatory measurements obtained from CAP-pretreated O3-exposed (CAP-O3) animals were exacerbated rather than diminished compared with the effects of O3 alone. Similarly, lavage fluid protein accumulation was enhanced in the CAP-O3 group compared with the O3-exposed group. In better agreement with our initial hypothesis, the CAP-O3 group was less responsive than the O3-exposed animals to histamine aerosol challenge. Additionally, Evans blue dye accumulation, a hallmark of tachykinin release, was increased in O3-exposed animals and was partially blocked in the CAP-O3 group. These data suggest that tachykinin-containing sensory fibers are unlikely to mediate the acute effects of O3 exposure on tidal breathing and lavage fluid protein accumulation but may play a role in causing post-O3 airway hyperreactivity and protein extravasation into the trachea.

• OSTI ID: 5506368
• Journal Information: Journal of Applied Physiology (1985); (United States), Journal Name: Journal of Applied Physiology (1985); (United States) Vol. 75:3; ISSN JAPHEV; ISSN 8750-7587
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALOIDS
AMINES
ANIMALS
AZO COMPOUNDS
AZO DYES
AZOLES
BIOLOGICAL EFFECTS
BODY
CAPSICUM
DYES
EVANS BLUE
FUNCTIONS
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
HISTAMINE
IMIDAZOLES
LUNGS
MAGNOLIOPHYTA
MAGNOLIOPSIDA
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OZONE
PLANTS
PROTEINS
REAGENTS
RESPIRATION
RESPIRATORY SYSTEM
RESPONSE FUNCTIONS
RESPONSE MODIFYING FACTORS
RODENTS
SULFONIC ACIDS
TRACHEA
VERTEBRATES