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Irradiation of para-aortic lymph node metastases from carcinoma of the cervix or endometrium

Journal Article · · Radiology; (United States)
OSTI ID:5504913
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Twenty-two patients with biopsy-proved para-aortic lymph node metastases from carcinoma of the cervix (15 patients) or endometrium (7 patients) received a median dose of 5,000 rad/25 fractions. Para-aortic nodal metastases were controlled in 77% of cases. Control was significantly lower following radical retroperitoneal lymph node dissection than less extensive sampling procedures. Obstruction of the small bowel developed in 3 patients with tumor recurrence in the para-aortic region. Eight of the 10 patients who were disease-free at 2 years received >5,000 rad. Three patients were still alive without disease at 129, 63, and 60 months, respectively. The 5-year disease-free survival rate was 40% for cervical cancer and 60% for endometrial cancer: in the former group, it was significantly different depending on whether the para-aortic nodes were irradiated (40%) or not (0%). The authors suggest that 5,000-5,500 rad in 5-5.5 weeks is well tolerated and can control aortic nodal metastases in cervical and possibly endometrial cancer.

Research Organization:
Medical Coll. of Wisconsin Affiliated Hospitals, Milwaukee
OSTI ID:
5504913
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 147:1; ISSN RADLA
Country of Publication:
United States
Language:
English

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Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANOREXIA
BODY
CARCINOMAS
DIARRHEA
DIGESTIVE SYSTEM DISEASES
DISEASES
ELECTROMAGNETIC RADIATION
FEMALE GENITALS
FISTULAE
HARD X RADIATION
IONIZING RADIATIONS
LYMPH NODES
LYMPHATIC SYSTEM
MEDICINE
METASTASES
NAUSEA
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PROCTITIS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SYMPTOMS
THERAPY
UTERUS
X RADIATION