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Late effects of para-aortic irradiation in carcinoma of the uterine cervix and endometrium

Conference · · Radiology; (United States)
OSTI ID:5300064
; ; ; ; ;

Twenty-one patients with cervical or endometrial carcinoma and metastases to the para-aortic lymph nodes were treated with extended-field para-aortic irradiation. The late effects of this treatment were evaluated in 16 patients who had a minimum follow-up of six months. All of the patients with massive pelvic tumors died of active disease in the pelvis with or without metastases. Three patients had small-bowel complications; none of the patients who underwent exploratory laparotomy for lymph node biopsy had bowel complications. The results indicate that patients with central lesions and minimal para-aortic disease benefit most from para-aortic irradiation. It is concluded that metastases to the para-aortic lymph nodes do not necessarily indicate more distant spread, and can be cured with irradiation. The late complication rate can be minimized by reducing the dosage to the small bowel with a combination of anterior-posterior fields and 360/sup 0/ rotation or opposing lateral 120/sup 0/ arc fields, and by using the extraperitoneal approach for lymph node biopsy.

Research Organization:
Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
OSTI ID:
5300064
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 135:3; ISSN RADLA
Country of Publication:
United States
Language:
English

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560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
ALKALINE EARTH ISOTOPES
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD VESSELS
BODY
BODY AREAS
CARCINOMAS
CARDIOVASCULAR SYSTEM
COBALT 60
COBALT ISOTOPES
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FEMALE GENITALS
FISTULAE
GAMMA RADIATION
GASTROINTESTINAL TRACT
IMPLANTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTERNAL IRRADIATION
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LINEAR ACCELERATORS
LYMPH NODES
LYMPHATIC SYSTEM
MALFORMATIONS
MEDICINE
METASTASES
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PELVIS
RADIATION EFFECTS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RADIUM ISOTOPES
SIDE EFFECTS
SMALL INTESTINE
THERAPY
UTERUS
YEARS LIVING RADIOISOTOPES