Effects of X irradiation on the growth of normal and hyperplastic mouse mammary gland transplants
To avoid the problems associated with whole-body radiation, pieces of X-irradiated normal or hyperplastic mammary tissue were transplanted to the host gland-free fat pad of nonexposed mice. The percentage of the fat pad filled by growth of the transplants at 4, 8, and 12 weeks after transplanation was measured. Growth of lobule transplants was moderately inhibited by 4 Gy. While some of the lobules survived 12 Gy, their growth was severely inhibited. The hyperplastic outgrowth lines were variable but more resitant than lobules to growth retardiation. Line Z5D was more susceptible than D/sub 1/, and Z5C/sub 1/ was least susceptible, with 88% growing well after 12 Gy. In order to distinguish between transient and permainent growth retardation, tissue was taken from the irradiated and control transplants and retransplanted to new hosts without further radiation. The second generation of X-ray-exposed tissue filled more of the fat pad than the first-generation transplants, but significantly less than the nonexposed controls. The experiments described provide a means of demonstrating X-ray-induced changes in the mammary gland from growth inhibition to carcinogenesis.
- OSTI ID:
- 5504597
- Journal Information:
- Radiat. Res.; (United States), Vol. 94:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MAMMARY GLANDS
BIOLOGICAL RADIATION EFFECTS
TRANSPLANTS
GROWTH
INHIBITION
MICE
RADIOINDUCTION
STATISTICS
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BODY
ELECTROMAGNETIC RADIATION
GLANDS
IONIZING RADIATIONS
MAMMALS
MATHEMATICS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals