Toxic effects in C57B1/6 and DBA/2 mice following consumption of halogenated aromatic hydrocarbon-contaminated Great Lakes coho salmon (Oncorhynchus kisutch Walbaum)
Journal Article
·
· Environ. Health Perspect.; (United States)
Diets containing coho salmon (Oncorhynchus kisutch Walbaum) from the Pacific Ocean or from Lakes Erie, Michigan, and Ontario (containing a gradation from low to high of halogenated aromatic hydrocarbons, (HAHs)) were fed to C57B1/6 and DBA/2 mice. Following a 4-month dietary exposure to Lake Ontario salmon, both strains of mice demonstrated hepatomegaly. The ethoxyresorufin-O-deethylase (ERR) enzyme levels were elevated in livers of C57B1/6 mice fed diets of salmon from all of the Great Lakes studied, with exceptionally high levels detected in C57B1/6 mice fed Lake Ontario salmon. Induction of ERR enzyme levels was detected in DBA/2 mice only following dietary exposure to Lake Ontario salmon. Serum levels of L-thyroxine (T4) and triiodo-L-thryonine (T3) were suppressed in C57B1/6 mice following consumption of Lake Ontario coho salmon, but T3 and T4 levels remained unchanged in DBA/2 mice. In general, pathobiological effects correlated with both dietary HAH exposure level and Ah receptor status.
- Research Organization:
- McMaster Univ. Medical Centre, Hamilton, Ontario
- OSTI ID:
- 5504356
- Journal Information:
- Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 75; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANADROMOUS FISHES
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BODY
CARBOXYLIC ACIDS
CONTAMINATION
DIET
DIGESTIVE SYSTEM
ENZYME ACTIVITY
ENZYMES
FISHES
FOOD CHAINS
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HORMONES
LIVER
MAMMALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEPTIDE HORMONES
POLLUTION
RODENTS
SALMON
THYROID HORMONES
THYROXINE
TOXICITY
TRIIODOTHYRONINE
VERTEBRATES
WATER POLLUTION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANADROMOUS FISHES
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BODY
CARBOXYLIC ACIDS
CONTAMINATION
DIET
DIGESTIVE SYSTEM
ENZYME ACTIVITY
ENZYMES
FISHES
FOOD CHAINS
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HORMONES
LIVER
MAMMALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEPTIDE HORMONES
POLLUTION
RODENTS
SALMON
THYROID HORMONES
THYROXINE
TOXICITY
TRIIODOTHYRONINE
VERTEBRATES
WATER POLLUTION