Immunomodulation in C57Bl/6 mice following consumption of halogenated aromatic hydrocarbon-contaminated coho salmon (Oncorhynchus kisutch) from Lake Ontario

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Journal of Toxicology and Environmental Health; (USA)

OSTI ID:5471204

Cleland, G B; McElroy, P J; Sonstegard, R A ^[1]

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1. McMaster Univ. Medical Centre, Hamilton, Ontario (Canada)

This report describes studies designed to assess the immunomodulatory effects associated with the consumption of coho salmon containing halogenated aromatic hydrocarbons (HAHs) and other compounds naturally bioaccumulated from Lake Ontario. Diets containing 33% coho salmon from Lake Ontario or the Pacific Ocean were fed to juvenile C57Bl/6 mice for 2-4 mo. Following 60 d, the mice that consumed Lake Ontario salmon had reduced IgM, IgG, and IgA plaque-forming cell responses to sheep erythrocytes. No changes were observed in total numbers of spleen lymphocytes, total T-lymphocytes or T-lymphocyte subsets as determined by flow cytometry. Cellular immunity, assessed by the cytotoxic T-lymphocyte response to allogeneic tumor target cells, was not altered following dietary exposure to Lake Ontario coho salmon for 4 mo. The observed humoral immunomodulation correlated with elevated PCB levels in the Lake Ontario salmon diets. The levels of pollutants such as mercury, tin compounds and other metals, PCDDs, and PCDFs were not examined.

• OSTI ID: 5471204
• Journal Information: Journal of Toxicology and Environmental Health; (USA), Journal Name: Journal of Toxicology and Environmental Health; (USA) Vol. 27:4; ISSN JTEHD; ISSN 0098-4108
• Country of Publication: United States
• Language: English

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54 ENVIRONMENTAL SCIENCES
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANADROMOUS FISHES
ANIMAL CELLS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL FLOW SYSTEMS
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE CELLS
CONTAMINATION
FISHES
FOOD CHAINS
GLOBULINS
GREAT LAKES
HALOGENATED AROMATIC HYDROCARBONS
IMMUNOGLOBULINS
LAKE ONTARIO
LAKES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PHENOTYPE
POLLUTION
PROTEINS
RODENTS
SALMON
SOMATIC CELLS
SPLEEN
SURFACE WATERS
TOXICITY
VERTEBRATES
WATER POLLUTION