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Female reproductive potential after treatment for Hodgkin's disease

Journal Article · · New Engl. J. Med.; (United States)
; ; ;
The probability of maintaining ovarian function, becoming pregnant, and delivering a normal child is important to young women anticipating successful therapy for Hodgkin's disease. In this study, reproductive function was retrospectively examined in 103 women 40 years old or younger who had undergone treatment for Hodgkin's disease with total-lymphoid irradiation (TLI) alone, combination chemotherapy, or combined TLI and chemotherapy. Infertility was directly related to gonadal exposure to therapy and to age at treatment. Twenty women became pregnant after receiving total-nodal irradiation or combination chemotherapy or both. No fetal wastage occurred, and no birth defects were seen in the 24 infants born to these women. Even after intensive treatment programs, women successfully treated for Hodgkin's disease have become pregnant and delivered phenotypically normal children.
OSTI ID:
5503929
Journal Information:
New Engl. J. Med.; (United States), Journal Name: New Engl. J. Med.; (United States) Vol. 304:23; ISSN NEJMA
Country of Publication:
United States
Language:
English

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Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
551000 -- Physiological Systems
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHEMOTHERAPY
DISEASES
FEMALES
HODGKINS DISEASE
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOMAS
MAMMALS
MAN
MEDICINE
NEONATES
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
PHENOTYPE
PREGNANCY
PRIMATES
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
REPRODUCTION
REPRODUCTIVE DISORDERS
SIDE EFFECTS
THERAPY
VERTEBRATES
WOMEN