Pregnancies and menstrual function before and after combined radiation (RT) and chemotherapy (TVPP) for Hodgkin's disease

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Cancer Invest.; (United States)

DOI:https://doi.org/10.3109/07357908609038252· OSTI ID:5269048

Lacher, M J; Toner, K

The menstrual cycle, pregnancies, and offspring were evaluated before and after initial combined radiation (RT) and chemotherapy with thiotepa, vinblastine, vincristine, procarbazine, and prednisone (TVPP), in 34 women between the ages of 18 and 44 (median 26.5 years) treated for Stage II and Stage III Hodgkin's disease. The median range of follow-up is 83.1 months (range 40.5-140). After therapy 94.1% (32/34) continued to menstruate. Two of the four patients over the age of 35 ceased to menstruate. All patients under the age of 35 continued to menstruate (30/30). Age at the time of diagnosis was the only factor affecting change in menses with a significant probability (p = .001) that women greater than 30 years of age will experience some change in menstrual pattern. Seventeen pregnancies occurred in 12 women after therapy; 2 had 4 elective abortions; 10 delivered 12 children with normal physical development; 1 will deliver six months from now. Twelve of thirteen patients who wanted to become pregnant have conceived. The ability to become pregnant and deliver normal children after intensive treatment with combined radiation and chemotherapy (RT/TVPP) was comparable to the patients' pretreatment record.

• Research Organization: Lymphoma/Hematology Service Memorial Hospital, New York, NY
• OSTI ID: 5269048
• Journal Information: Cancer Invest.; (United States), Journal Name: Cancer Invest.; (United States) Journal Issue: 2 Vol. 2; ISSN CINVD
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ALKALOIDS
ANIMALS
ANTIMITOTIC DRUGS
AROMATICS
AZAARENES
AZOLES
CHEMOTHERAPY
CORTICOSTEROIDS
DISEASES
DRUGS
FEMALES
FERTILITY
GLUCOCORTICOIDS
HETEROCYCLIC COMPOUNDS
HODGKINS DISEASE
HORMONES
HYDROXY COMPOUNDS
INDOLES
KETONES
LYMPHOMAS
MAMMALS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
PREDNISONE
PREGNANCY
PREGNANES
PRIMATES
PYRROLES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
STEROID HORMONES
STEROIDS
THERAPY
VERTEBRATES
VINBLASTINE
WOMEN