Late effects on gonadal function of cyclophosphamide, total-body irradiation, and marrow transplantation
One hundred thirty-seven patients had gonadal function evaluated 1-11 years after marrow transplantation. All 15 women less than age 26 and three of nine older than age 26 who were treated with 200 mg/kg cyclophosphamide recovered normal gonadotropin levels and menstruation. Five have had five pregnancies resulting in three live births, one spontaneous abortion, and one elective abortion. Three of 38 women who were prepared with 120 mg/kg cyclophosphamide and 920-1200 rad total-body irradiation had normal gonadotropin levels and menstruation. Two had pregnancies resulting in one spontaneous and one elective abortion. Of 31 men prepared with 200 mg/kg cyclophosphamide, 30 had normal luteinizing hormone levels, 20 had normal follicle-stimulating hormone levels, and 10 of 15 had spermatogenesis. Four have fathered five normal children. Thirty-six of 41 men prepared with 120 mg/kg cyclophosphamide and 920-1750 rad total-body irradiation had normal luteinizing hormone levels, ten had normal follicle-stimulating hormone levels, and 2 of 32 studied had spermatogenesis. One has fathered two normal children. It was concluded that cyclophosphamide does not prevent return of normal gonadal function in younger women and in most men. Total-body irradiation prevents return of normal gonadal function in the majority of patients.
- Research Organization:
- Fred Hutchinson Cancer Research Center, Seattle, Washington
- OSTI ID:
- 5502430
- Journal Information:
- Transplantation; (United States), Vol. 36:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BONE MARROW
TRANSPLANTS
ENDOXAN
BIOLOGICAL EFFECTS
FSH
BLOOD CHEMISTRY
LH
OVARIES
DELAYED RADIATION EFFECTS
TESTES
FEMALES
FERTILITY
LEUKEMIA
MALES
PATIENTS
PREGNANCY
SPERMATOGENESIS
WHOLE-BODY IRRADIATION
ALKYLATING AGENTS
ANIMAL TISSUES
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
DRUGS
EXTERNAL IRRADIATION
FEMALE GENITALS
GAMETOGENESIS
GONADOTROPINS
GONADS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HORMONES
IMMUNOSUPPRESSIVE DRUGS
IRRADIATION
MALE GENITALS
NEOPLASMS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
TISSUES
560151* - Radiation Effects on Animals- Man
551000 - Physiological Systems