Effects of postoperative adjuvant chemotherapy and radiotherapy on ovarian function in women undergoing treatment for soft tissue sarcoma

Journal Article · Tue Dec 01 04:00:00 EST 1981 · J. Natl. Cancer Inst.; (United States)

OSTI ID:5514132

Shamberger, R C ^[1]; Sherins, R J; Ziegler, J L; Glatstein, E; Rosenberg, S A

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1. National Inst. of Health, Bethesda, MD

Ovarian function was evaluated in 11 women 16 to 43 years of age at treatment who received doxorubicin, cyclophosphamide, and high doses of methotrexate with or without radiotherapy in adjuvant therapy of soft tissue sarcoma. Five women (16-33 yr old) who received chemotherapy alone or combined with radiotherapy only at sites distant from the ovaries (chest wall, thigh, and leg) had minimal menstrual irregularities or temporary cessation of menses during therapy; cyclic menses returned promptly after therapy. Gonadotropin levels (expressed as means +/- SD) (follicle-stimulating hormone (FSH), 10 +/- 15 mlU/ml; luteinizing hormone (LH), 10 +/- 4 mlU/ml) and 17 ..beta..-estradiol (E/sub 2/) levels (means +/- SD, 208 +/- 147 pg/ml) were normal. By contrast, 4 older women (ages 36-43 yr) who received similar treatment developd persistent amenorrhea with postmenopausal levels of gonadotropin (FSH, 109 +/- 29 mlU/ml; LH, 72 +/- 19 mlU/ml) and E/sub 2/ (19 +/- 8 pg/ml). Two additional women (ages 21 and 39 yr) who received radiation (7000 rad) to the pelvis plus chemotherapy developed prompt cessation of menses and became functional castrates (FSH, 77 and 80mlU/ml; LH, 40 and 58 mlU/ml; E/sub 2/, 10 and 19 pg/ml). However, this result would be expected from the radiation dose alone. The data demonstrated that ovarian dysfunction may follow the use of doxorubicin, cyclophosphamide, and high doses of methotrexate and that the injury is age related.

• OSTI ID: 5514132
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 67:6; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
BODY
CHEMOTHERAPY
DISEASES
EXTERNAL IRRADIATION
FEMALE GENITALS
FSH
GONADOTROPINS
GONADS
HORMONES
INJURIES
IRRADIATION
LH
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
OVARIES
PATIENTS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOLOGY
RADIOTHERAPY
SARCOMAS
SIDE EFFECTS
THERAPY
TISSUES