Comparative cardiac effects of three hepatobiliary radiopharmacologicals in the dog: concise communication

Journal Article · Thu Apr 01 00:00:00 EST 1982 · J. Nucl. Med.; (United States)

OSTI ID:5500335

Shani, J ^[1]; Rogel, S; Weininger, J; Lubin, E

---

1. Hadassah Univ. Hospital, Jerusalem, Isreal

Three hepatobiliary agents with an acetanilide-imidoacetic-acid moiety resembling that in lidocaine were investigated for their possible effects on contractility and conductivity in the heart and on arterial pressure and aortic blood flow. This was done in the light of lidocaine's numerous cardiac side effects. HIDA, BIDA, and DIPA, each with traces of decayed Tc-99m, were injected i.v. into anesthetized dogs with an A-V block, and their effects on the above parameters were followed until control levels were reestablished. Wheras lidocaine raises the diastolic threshold and prolongs the refractory period, the three agents tested do not prolong myocardial conductivity. Both HIDA and BIDA have an effect similar to that of lidocaine, but DIPA has no effect on the latter two parameters. Moreover, whereas lidocaine depresses myocardial contractility, blood pressure, and blood flow, HIDA has a less prominent effect on these parameters, and neither BIDA nor DIPA has any such effect. It is concluded that even though the effect of HIDA on the heart is milder than that of lidocaine, the effects of both BIDA and DIPA are even less pronounced, and they are less likely to cause cardiac side effects when similar doses are administered during nuclear medicine procedures.

• OSTI ID: 5500335
• Journal Information: J. Nucl. Med.; (United States), Vol. 23:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
BIOLOGICAL RADIATION EFFECTS
RADIOPHARMACEUTICALS
SIDE EFFECTS
ACETIC ACID
BLOOD FLOW
COMPARATIVE EVALUATIONS
DOGS
ISOMERIC NUCLEI
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MONOCARBOXYLIC ACIDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
550601 - Medicine- Unsealed Radionuclides in Diagnostics