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Title: Ruthenium-97 hepatobiliary agents for delayed studies of the bilary tract I: Ru-97 PIPIDA: concise communication

Abstract

Failure of early diagnosis of biliary atresia results in the development of cirrhosis and death. Commonly used hepatobiliary agents are not ideal for follow-up studies because of their unfavorable physical properties or short half-life. The excellent physical properties of Ru-97 should overcome these limitations. Therefore, Ru-97 PIPIDA (N,..cap alpha..-(p-isopropyl acetanilide) iminoacetic acid) is being investigated as a potential hepatobiliary agent that would allow an improved diagnosis of the disease. Ruthenium-97 PIPIDA and Tc-99m PIPIDA showed similar blood clearance rates in dogs. Ru-97 PIPIDA scintigrams in dogs showed early uptake in liver and gallbladder and slow excretion through the gastrointestinal tract. Biodistribution studies were performed in normal rats and rats with biliary obstruction. The findings suggest that Ru-97 PIPIDA should be useful for delayed studies ( 1 to 3 days) of the biliary tract.

Authors:
; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Brookhaven National Lab., Upton, NY
OSTI Identifier:
6582521
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Journal Article
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 22:4
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; BILIARY TRACT; SCINTISCANNING; DIGESTIVE SYSTEM DISEASES; DIAGNOSIS; RUTHENIUM 97; DIAGNOSTIC USES; RADIONUCLIDE KINETICS; ACETIC ACID ESTERS; BIOLOGICAL HALF-LIFE; BLOOD-PLASMA CLEARANCE; CHEMICAL PREPARATION; COMPARATIVE EVALUATIONS; DOGS; DYNAMIC FUNCTION STUDIES; EXCRETION; ISOMERIC NUCLEI; PATIENTS; RATS; TECHNETIUM 99; TIME DEPENDENCE; UPTAKE; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACID ESTERS; CLEARANCE; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; ESTERS; EVEN-ODD NUCLEI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RODENTS; RUTHENIUM ISOTOPES; SYNTHESIS; TECHNETIUM ISOTOPES; USES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987); 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Schachner, E R, Gil, M C, Atkins, H L, Som, P, Srivastava, S C, Badia, J, Sacker, D F, Fairchild, R G, and Richards, P. Ruthenium-97 hepatobiliary agents for delayed studies of the bilary tract I: Ru-97 PIPIDA: concise communication. United States: N. p., 1981. Web.
Schachner, E R, Gil, M C, Atkins, H L, Som, P, Srivastava, S C, Badia, J, Sacker, D F, Fairchild, R G, & Richards, P. Ruthenium-97 hepatobiliary agents for delayed studies of the bilary tract I: Ru-97 PIPIDA: concise communication. United States.
Schachner, E R, Gil, M C, Atkins, H L, Som, P, Srivastava, S C, Badia, J, Sacker, D F, Fairchild, R G, and Richards, P. 1981. "Ruthenium-97 hepatobiliary agents for delayed studies of the bilary tract I: Ru-97 PIPIDA: concise communication". United States.
@article{osti_6582521,
title = {Ruthenium-97 hepatobiliary agents for delayed studies of the bilary tract I: Ru-97 PIPIDA: concise communication},
author = {Schachner, E R and Gil, M C and Atkins, H L and Som, P and Srivastava, S C and Badia, J and Sacker, D F and Fairchild, R G and Richards, P},
abstractNote = {Failure of early diagnosis of biliary atresia results in the development of cirrhosis and death. Commonly used hepatobiliary agents are not ideal for follow-up studies because of their unfavorable physical properties or short half-life. The excellent physical properties of Ru-97 should overcome these limitations. Therefore, Ru-97 PIPIDA (N,..cap alpha..-(p-isopropyl acetanilide) iminoacetic acid) is being investigated as a potential hepatobiliary agent that would allow an improved diagnosis of the disease. Ruthenium-97 PIPIDA and Tc-99m PIPIDA showed similar blood clearance rates in dogs. Ru-97 PIPIDA scintigrams in dogs showed early uptake in liver and gallbladder and slow excretion through the gastrointestinal tract. Biodistribution studies were performed in normal rats and rats with biliary obstruction. The findings suggest that Ru-97 PIPIDA should be useful for delayed studies ( 1 to 3 days) of the biliary tract.},
doi = {},
url = {https://www.osti.gov/biblio/6582521}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 22:4,
place = {United States},
year = {Wed Apr 01 00:00:00 EST 1981},
month = {Wed Apr 01 00:00:00 EST 1981}
}