Influence of dietary iron level and form on biochemical, hematological, and immunological changes in copper deficient rats

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5498199

Leu, H; Gallaher, D D; Kramer, T R

Weanling male Lewis rats (N = 10/group) were fed ad-libitum for 42 days diets based on AIN standards containing 21% casein, 5% safflower oil, deficient (0.6 ..mu..g/g) or adequate (5.6 ..mu..g/g) levels of Cu, and adequate (50 ..mu..g/g) or high (300 ..mu..g/g) levels of Fe/sup +2/ or Fe/sup +3/. Cu-deficient rats, regardless of Fe level or form, exhibited depressed (p < 0.05) serum Cu, Fe and ceruloplasmin activity, and hemoglobin levels; and elevated (p < 0.05) unsaturated serum Fe binding capacity. Except for high Fe/sup +3/ fed rats, Cu-deficient rats showed decreased hematocrits. Decreased proliferation was exhibited by concanavalin-A (Con-A) stimulated spleen lymphoid cells (SLC) of Cu-deficient rats fed adequate dietary Fe, but not by SLC of Cu-deficient rats fed high dietary Fe. High Fe fed rats exhibited reduced proliferation and increased variability in proliferation by Con-A stimulated SLC, which apparently caused a lack of difference in proliferation by SLC of Cu-deficient and Cu-adequate rats fed high Fe. Thus, high dietary Fe did not correct biochemical and hematological parameters in Cu-deficient rats, but because of lowered proliferation and increased variability of SLC proliferation, high dietary Fe did alleviate suppressed Con-A stimulated SLC proliferation in Cu-deficiency.

• Research Organization: Dept. of Agriculture, Grand Forks, ND
• OSTI ID: 5498199
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLUTININS
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BLOOD COUNT
CARBOXYLIC ACIDS
CELL PROLIFERATION
CONCANAVALIN
COPPER
DIET
ELEMENTS
GLOBIN
HEMAGGLUTININS
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IRON
LECTINS
MAMMALS
METALS
NUTRITIONAL DEFICIENCY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RATS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
TRANSITION ELEMENTS
VERTEBRATES