Logistic regression analysis of cadmium-induced renal abnormalities

Conference · Sat Feb 01 04:00:00 EST 1986

OSTI ID:5497797

Ellis, K J; Yuen, K; Cohn, S H

Cases of renal dysfunction associated with cadium exposure have been reported in Belgium, Great Britian, Japan, United States, and Sweden. Indirect estimates of body burden were often based on the measurement of environmental exposure conditions or on tissue concentrations in urine, blood, saliva, or hair clippings. More recently, however, the direct in vivo assessment of liver and kidney cadmium burden in humans has provided additional data. Sufficient data on humans does exist, however, to make reasonable estimates of the increased risk for cadmium-induced renal dysfunction. In the present paper, a linear logistic regression model has been developed on the basis of liver and kidney cadmium burden. These relationships are discussed with respect to the concept of a critical concentration for the renal cortex. 14 refs., 3 figs., 2 tabs.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5497797
• Report Number(s): BNL-38374; CONF-860297-1; ON: DE86014174
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AUTOPSY
BODY
BODY BURDEN
CADMIUM
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
GLOMERULI
KIDNEYS
LIVER
MATHEMATICS
METALS
ORGANS
PATHOLOGICAL CHANGES
REGRESSION ANALYSIS
RISK ASSESSMENT
STATISTICS