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One carbon metabolism in anaerobic bacteria: Regulation of carbon and electron flow during organic acid production: Progress report, February 1, 1987-February 1, 1988

Technical Report ·
OSTI ID:5497078
These studies concern the fundamental biochemical mechanisms that control carbon and electron flow in anaerobic bacteria that conserve energy when coupling hydrogen consumption to the production of acetic, propionic, or butyric acids. Two acidogens, Propionispira arboris and Butyribacterium methylotrophicum were chosen as model systems to understand the function of oxidoreductases and electron carriers in the regulation of hydrogen metabolism and single carbon metabolism. In P. arboris, H/sub 2/ consumption was linked to the inhibition of CO/sub 2/ production and an increase in the propionate/acetate rate; whereas, H/sub 2/ consumption was linked to a stimulation of CO/sub 2/ consumption and an increase in the butyrate/acetate ratio in B. methylotrophicum. We report studies on the enzymes involved in the regulation of singe carbon metabolism, the enzyme activities and pathways responsible for conversion of multicarbon components to acetate and propionate or butyrate, and how low pH inhibits H/sub 2/ and acetic acid production in Sarcina ventriculi as a consequence of hydrogenase regulation. 9 refs.
Research Organization:
Michigan Biotechnology Inst., Lansing (USA)
DOE Contract Number:
FG02-87ER13719
OSTI ID:
5497078
Report Number(s):
DOE/ER/13719-1; ON: DE88006629
Country of Publication:
United States
Language:
English