Recent advances in neutron capture therapy (NCT)
Conference
·
OSTI ID:5489510
The application of the /sup 10/B(n,..cap alpha..)/sup 7/Li reaction to cancer radiotherapy (Neutron Capture therapy, or NCT) has intrigued investigators since the discovery of the neutron. This paper briefly summarizes data describing recently developed boronated compounds with evident tumor specificity and extended biological half-lives. The implication of these compounds to NCT is evaluated in terms of Therapeutic Gain (TG). The optimization of NCT using band-pass filtered beams is described, again in terms of TG, and irradiation times with these less intense beams are estimated. 24 refs., 3 figs., 3 tabs.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5489510
- Report Number(s):
- BNL-37977; CONF-8510315-2; ON: DE86010540
- Country of Publication:
- United States
- Language:
- English
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·
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Related Subjects
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BORON COMPOUNDS
BORON HYDRIDES
DISEASES
GLIOMAS
HYDRIDES
HYDROGEN COMPOUNDS
MEDICINE
MEMBRANE TRANSPORT
NEOPLASMS
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
THERAPY
THIOLS
62 RADIOLOGY AND NUCLEAR MEDICINE
BORON COMPOUNDS
BORON HYDRIDES
DISEASES
GLIOMAS
HYDRIDES
HYDROGEN COMPOUNDS
MEDICINE
MEMBRANE TRANSPORT
NEOPLASMS
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
THERAPY
THIOLS