Differential effects of chronic lead intoxication on circadian rhythm of ambulatory activity and on regional brain norepinephrine levels in rats

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01623478· OSTI ID:5487873

Shafiq-ur-Rehman,; Khushnood-ur-Rehman,; Kabir-ud-Din,; Chandra, O

Changes in biochemical mechanisms and amine concentrations in the brain have been manifested in the form of varying disorders and abnormalities in behavior, including motor-activity, which has been proved with a number of psychoactive drugs. It has been reported that increased level of cerebral norepinephrine (NE) has been shown to be associated with motor hyper-activity, and in lead exposed rats. No study is available which could account for the pattern of changes in spontaneous ambulatory responses in an open field situation together with the steady state regional levels of NE in the brain of chronically lead exposed rats. Therefore, it seemed to be worthwhile to study the circadian rhythm of ambulatory activity and its association with NE levels in various brain regions of rats exposed to lead.

• Research Organization: Aligarh Muslim Univ., India
• OSTI ID: 5487873
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 36:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LEAD
CHRONIC EXPOSURE
NORADRENALINE
BIOCHEMISTRY
ABSORPTION SPECTROSCOPY
BEHAVIOR
BRAIN
DAILY VARIATIONS
EXPERIMENTAL DATA
RATS
ADRENAL HORMONES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHEMISTRY
DATA
DRUGS
ELEMENTS
HORMONES
INFORMATION
MAMMALS
METALS
NERVOUS SYSTEM
NEUROREGULATORS
NUMERICAL DATA
ORGANS
RODENTS
SPECTROSCOPY
STEROID HORMONES
SYMPATHOMIMETICS
VARIATIONS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)