cap alpha. -Methyl-p-tyrosine shifts circadian temperature rhythms
Journal Article
·
· Am. J. Physiol.; (United States)
OSTI ID:6324259
..cap alpha..-Methyl-p-tyrosine shifts the acrophase (time of highest temperature) of the circadian temperature rhythm of the rat to earlier or later times of day depending on the phase of the cicadian cycle at which the drug is administered. When ..cap alpha..-methyl-p-tyrosine methyl ester HCl is injected intraperitoneally at a dose of 100 mg/kg late in the projected 8-h light phase, the acrophase of the intraperitoneal temperature rhythm is delayed by up to 3 h.However, when the same dose of drug is given 9-10 h into the projected 16-h dark phase of the daily cycle, the acrophase of the temperature rhythm occurs about 2 h earlier than expected. The times of ..cap alpha..-methyl-p-tyrosine administration leading to maximal phase delays or advances are correlated with the times of minimal and maximal turnover of norepinephrine in the hypothalamus. These results suggest that changing rates of norepinephrine turnover in the hypothalamus may regulate the circadian temperature rhythm in rats. The results also emphasize the fact that the effects of drugs may vary as a function of the time of administration. This fact must be taken into account in pharmacologic testing.
- Research Organization:
- Argonne National Lab., IL
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 6324259
- Journal Information:
- Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 243:3; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Chronotypic induction of tyrosine aminotransferase by. cap alpha. -methyl-p-tyrosine. [Rat liver]
Chronopharmacology of L-DOPA: implications for orthochronal therapy in the prevention of circadian dyschronism
Effects of bile acid administration on bile acid synthesis and its circadian rhythm in man
Journal Article
·
Sun Apr 05 23:00:00 EST 1981
· Life Sci.; (United States)
·
OSTI ID:6569045
Chronopharmacology of L-DOPA: implications for orthochronal therapy in the prevention of circadian dyschronism
Conference
·
Sat Dec 31 23:00:00 EST 1977
·
OSTI ID:6845361
Effects of bile acid administration on bile acid synthesis and its circadian rhythm in man
Journal Article
·
Thu Sep 01 00:00:00 EDT 1988
· Hepatol.; (United States)
·
OSTI ID:6758303
Related Subjects
551000 -- Physiological Systems
560205* -- Thermal Effects-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
AMINO ACIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BODY
BRAIN
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CONTROL
DAILY VARIATIONS
DRUGS
FUNCTIONS
HORMONES
HYPOTHALAMUS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RATS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
TEMPERATURE CONTROL
THERMOREGULATION
VARIATIONS
VERTEBRATES
560205* -- Thermal Effects-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
AMINO ACIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BODY
BRAIN
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CONTROL
DAILY VARIATIONS
DRUGS
FUNCTIONS
HORMONES
HYPOTHALAMUS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RATS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
TEMPERATURE CONTROL
THERMOREGULATION
VARIATIONS
VERTEBRATES