Effects of silica dust inhalation on the susceptibility of mice to influenza infection
Mice were exposed to silica dust for durations of up to 36 wk. At intervals of 15, 21, 27, 33, and 36 wk, the ability of the splenic lymphocytes to respond to T and B cell mitogens were determined, and their ability to resist influenza virus infections was determined after 3 and 20 wk of exposure. These exposures had a depressing effect on the response to T cell mitogens at 21 and 27 wk of silica exposure, but there was no effect on the T cell responses after 15, 33, and 36 wk or on B cell responses after all exposure times. No changes could be detected in the ability of the mice to resist pulmonary influenza virus infections or in the survivors' ability to form HI antibodies against this virus.
- Research Organization:
- Center for Air Environment Studies, University Park, PA
- OSTI ID:
- 5486716
- Journal Information:
- Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 34:5; ISSN AEHLA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Evaluation of effects of ozone exposure on influenza infection in mice using several indicators of susceptibility
CONTINUOUS COBALT-60 IRRADIATION AND IMMUNITY TO INFLUENZA VIRUS
Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHALCOGENIDES
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
DISEASES
DUSTS
INFECTIOUS DISEASES
INFECTIVITY
INFLUENZA
INFLUENZA VIRUSES
INHALATION
INTAKE
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MICROORGANISMS
MINERALS
MITOGENS
OXIDES
OXYGEN COMPOUNDS
PARASITES
RESPONSE MODIFYING FACTORS
RODENTS
SENSITIVITY
SILICA
SILICON COMPOUNDS
SILICON OXIDES
SOMATIC CELLS
VERTEBRATES
VIRUSES