Effect of unlabeled indium oxine and indium tropolone on the function of isolated human lymphocytes
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5483562
The purpose of this study was to compare the effect of indium oxine and indium-tropolone complexes (nonradiolabeled) on the function of isolated human lymphocytes. Peripheral lymphocytes were obtained from 15 normal volunteers and incubated with indium oxine or indium tropolone according to the standard techniques currently used when cells are radiolabeled for subsequent in vivo studies. The phytohemagglutinin-induced (PHA) lymphocyte transformation and a more specific lymphocyte functional test (the mixed lymphocyte reaction) were performed following incubation with the indium complexes. The results indicate that PHA transformation is not affected by either indium oxine or indium tropolone, whereas both chelates reduced the mixed lymphocyte reaction. This suggests that these substances have a selective toxic effect only on a functionally distinct lymphocyte subset and indicates that there is no significant difference between the two indium chelates in terms of their effect on lymphocyte function.
- Research Organization:
- Univ. of Rome, Italy
- OSTI ID:
- 5483562
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:6; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparison of oxine and tropolone methods for labeling human platelets with indium-111
Indium-111 labeling of leukocytes: a detrimental effect on neutrophil and lymphocyte function and an improved method of cell labelling
Toxicity of indium-111 on the radiolabeled lymphocyte
Journal Article
·
Mon Dec 31 23:00:00 EST 1990
· Journal of Nuclear Medicine; (USA)
·
OSTI ID:5894059
Indium-111 labeling of leukocytes: a detrimental effect on neutrophil and lymphocyte function and an improved method of cell labelling
Journal Article
·
Tue Oct 31 23:00:00 EST 1978
· J. Nucl. Med.; (United States)
·
OSTI ID:6203551
Toxicity of indium-111 on the radiolabeled lymphocyte
Journal Article
·
Sat Jan 31 23:00:00 EST 1987
· J. Nucl. Med.; (United States)
·
OSTI ID:6646503
Related Subjects
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
AZAARENES
AZINES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL PROLIFERATION
CHELATING AGENTS
CONNECTIVE TISSUE CELLS
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDIUM COMPOUNDS
KETONES
LABELLED COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXINE
PRIMATES
PYRIDINES
QUINOLINES
RADIOPHARMACEUTICALS
SOMATIC CELLS
TOXICITY
TROPONES
VERTEBRATES
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
AZAARENES
AZINES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL PROLIFERATION
CHELATING AGENTS
CONNECTIVE TISSUE CELLS
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDIUM COMPOUNDS
KETONES
LABELLED COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXINE
PRIMATES
PYRIDINES
QUINOLINES
RADIOPHARMACEUTICALS
SOMATIC CELLS
TOXICITY
TROPONES
VERTEBRATES