Stable xenon CT blood flow mapping for evaluation of patients with extracranial-intracranial bypass surgery

Journal Article · Fri Mar 01 04:00:00 EST 1985 · J. Neurosurg.; (United States)

DOI:https://doi.org/10.3171/jns.1985.62.3.0324· OSTI ID:5483236

Yonas, H; Gur, D; Good, B C; Latchaw, R E; Wolfson, Jr, S K; Good, W F; Maitz, G S; Colsher, J G; Barnes, J E; Colliander, K G

Xenon computerized tomography (Xe CT) blood flow studies were conducted in 25 patients referred for a possible extracranial-intracranial bypass procedure for occlusive vascular disease in one or more extra- or intracranial vessels. These studies were helpful in selecting eight candidates for surgery. The Xe CT studies were performed at one or two brain levels using a prototype Xe CT system for measurement of cerebral blood flow which was designed in collaboration with the General Electric Co., and adapted for the GE 9800 scanner. In those patients selected to undergo operation, Xe CT demonstrated compromise of flow reserve regionally, globally, and/or in the watershed area. All eight patients who underwent the procedure showed a favorable clinical response postoperatively, and seven had a dramatic increase in flow. The 17 patients whose baseline CT studies showed no reduction of flow with the Xe CT method were not selected for surgery. All 25 patients have remained neurologically stable to date. Case studies of three of the eight patients undergoing bypass surgery are presented. This limited but consistent experience suggests that Xe CT blood flow mapping makes possible the recognition of brain regions in which flow reserves are compromised. This is due to the relatively high degree of spatial resolution that this technique provides and to the fact that mapping can be correlated directly with the anatomy. Used in combination with a careful clinical examination and an accurate medical history, this study method appears to be a useful guide in the selection of patients who are most at risk from hemodynamic instability and those who are most likely to benefit from flow-augmentation surgery.

• Research Organization: Univ. of Pittsburgh, PA
• OSTI ID: 5483236
• Journal Information: J. Neurosurg.; (United States), Journal Name: J. Neurosurg.; (United States) Vol. 62:3; ISSN JONSA
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD CIRCULATION
BLOOD VESSELS
BODY
BRAIN
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
ELEMENTS
FLUIDS
GASES
MEDICINE
NERVOUS SYSTEM
NONMETALS
ORGANS
PATIENTS
RARE GASES
SURGERY
THERAPY
TOMOGRAPHY
VASCULAR DISEASES
XENON