Pulmonary retention and tissue distribution of {sup 239}Pu nitrate in F344 rats and syrian hamsters inhaling carbon tetrachloride

Technical Report · Tue Nov 01 04:00:00 EST 1994

OSTI ID:54828

Benson, J M; Barr, E B; Lundgren, D L; Nikula, K J

Carbon tetrachloride (CCl{sub 4}) has been used extensively in the nuclear weapons industry, so it is possible that nuclear plant workers have been exposed to CCl{sub 4} and plutonium compounds. Potential for future exposure exists during {open_quotes}cleanup{close_quotes} operations at weapon production sites such as the Hanford, Washington, and Rocky Flats, Colorado, facilities. The current Threshold Limit Value for CCl{sub 4} is 5 ppm; however, concentrations of CCl{sub 4} occurring in the nuclear weapons facilities over the past 40-50 y are unknown and may have exceeded this value. The pilot study described in this report is designed to determine whether subchronic inhalation of CCl{sub 4} by CDF{sup register}(F-344)/CrlBR rats and Syrian golden hamsters, at concentrations expected to produce some histologic changes in liver, alters the hepatic retention and toxic effects of inhaled {sup 239}Pu nitrate {sup 239}Pu(NO{sub 3}){sub 4}.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 54828
• Report Number(s): ITRI--144; ON: DE95007526
• Country of Publication: United States
• Language: English

Related Subjects

05 NUCLEAR FUELS
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL EFFECTS
CARBON TETRACHLORIDE
DECONTAMINATION
DOSE LIMITS
HAMSTERS
INHALATION
LIVER
OCCUPATIONAL EXPOSURE
PATHOLOGICAL CHANGES
PLUTONIUM NITRATES
PROGRESS REPORT
RATS
RETENTION