Late biological effects of {sup 137}CsCl injected in beagle dogs
Technical Report
·
OSTI ID:54808
The toxicity of intravenously administered {sup 137}CsCl in the Beagle dog was investigated as part of the ITRI program to evaluate the biological effects of internally deposited fission product radionuclides. The toxicity and health effects of {sup 137}Cs are important to understand because {sup 137}Cs is produced in large amounts in light-water nuclear reactors. Also, large quantities of cesium radioisotopes have entered the human food chain as a result of atmospheric nuclear weapons tests and additonal cesium radioisotopes were released during the Chernobyl accident. The intravenous route of exposure was chosen because it was known that after intravenous injection, inhalation, or ingestion, internally deposited {sup 137}CsCl is rapidly adsorbed and distributed throughout the body, exposing the whole body to beta and gamma radiation, and because of the reduced radiation protection problems associated with high-level exposure via injection compared to these other routes.
- Research Organization:
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
- OSTI ID:
- 54808
- Report Number(s):
- ITRI--144; ON: DE95007526
- Country of Publication:
- United States
- Language:
- English
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