Biological effects of cesium-137 injected in beagle dogs of different ages

Technical Report · Fri Dec 01 04:00:00 EST 1995

DOI:https://doi.org/10.2172/381374· OSTI ID:381374

Nikula, K. J.; Muggenburg, B. A.; Griffith, W. C. ^[1]

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1. and others

The toxicity of cesium-137 ({sup 137}Cs) in the Beagle dog was investigated at the Argonne National Laboratory (ANL) as part of a program to evaluate the biological effects of internally deposited radionuclides. The toxicity and health effects of {sup 137}Cs are important to understand because {sup 137}Cs is produced in large amounts in light-water nuclear reactors. Large quantities of cesium radioisotopes have entered the human food chain as a result of atmospheric nuclear weapons test, and additional cesium radioisotopes were released during the Chernobyl accident. Although the final analyses are not complete, three findings are significant: older dogs dies significantly earlier than juvenile and young adult dogs; greater occurrence of sarcomas in the cesium-137 injected dogs; the major nonneoplastic effect in dogs surviving beyond 52 d appears to be testicular atrophy.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 381374
• Report Number(s): ITRI--146; ON: DE96008986
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BEAGLES
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
CESIUM 137
PROGRESS REPORT
STERILITY
TOXICITY