Inhibition of cholesterol-induced increases in arterial wall permeability by propranolol

Journal Article · Tue Dec 01 04:00:00 EST 1987 · J. Surg. Res.; (United States)

DOI:https://doi.org/10.1016/0022-4804(87)90132-6· OSTI ID:5479494

Sasaki, K; LaMorte, W W; Nickerson, C J; Fuller, R M; Chobanian, A V; Menzoian, J O

Increased arterial permeability to (/sup 125/I)albumin is one of the earliest abnormalities found in the cholesterol-fed rabbit model for atherosclerosis and precedes morphologic changes in the arterial wall. Since propranolol is reported to retard atherogenesis in this model, the current study was undertaken to study the effect of propranolol on arterial permeability to albumin in cholesterol-fed rabbits. Carotid permeability to (/sup 125/I)albumin was measured after 1 week of (a) a control diet containing only trace cholesterol (N = 9), (b) a 1.5% cholesterol diet (N = 11), or (c) a 1.5% cholesterol diet plus intraperitoneal propranolol 5 mg/kg/day (N = 19). The carotid artery was cannulated proximally and distally and peristaltically perfused with oxygenated Modified Eagle's Medium to which (/sup 125/I)albumin had been added. The permeability of the carotid artery to albumin was estimated by measuring /sup 125/I activity in peripheral venous samples obtained after 0, 15, 30, 60, 120, 180, and 240 min of carotid perfusion. /sup 125/I-radioactivity of the perfused carotid artery was also counted at the end of the experiment to measure /sup 125/I retained in the arterial wall. The transfer of (/sup 125/I)albumin across the arterial wall to the venous circulation was greater in the untreated cholesterol-fed group than in controls (P less than 0.05), but cholesterol-fed animals treated with propranolol did not differ significantly from controls. /sup 125/I-albumin in the arterial wall after 240 min of perfusion was decreased in both untreated cholesterol-fed animals (1444 dpm/cm +/- 350) and in propranolol-treated animals (1629 +/- 309) when these were compared to controls (3909 +/- 693, P less than .05).

• Research Organization: Boston Univ. Medical Center, MA
• OSTI ID: 5479494
• Journal Information: J. Surg. Res.; (United States), Journal Name: J. Surg. Res.; (United States) Vol. 43:6; ISSN JSGRA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
ALCOHOLS
ANIMAL TISSUES
ANIMALS
ARTERIES
ARTERIOSCLEROSIS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CELL WALL
CHOLESTEROL
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HYDROXY COMPOUNDS
INHIBITION
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MEMBRANE TRANSPORT
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PERFUSED TISSUES
PERMEABILITY
PROPANOLS
PROTEINS
RABBITS
RADIOISOTOPES
STEROIDS
STEROLS
TISSUES
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES