Relationship between alkylation sites and induction of dominant lethals and heritable translocations in mice

Conference · Tue Jan 01 04:00:00 EST 1985

OSTI ID:5478700

Generoso, W M

Production of dominant lethals and heritable translocations appears to be determined by the degree of stability of alkylation products within the chromosome. If repair is not effected in the fertilized eggs and the alkylation products persist to the time of pronuclear chromosome replication or early cleavage divisions, they lead to chromatid-type aberrations and eventually to lethality. The production of heritable translocations requires a transformation of unstable alkylation products into suitable intermediate lesions. These lesions are then converted into chromosome exchanges prior to the time of pronuclear chromosome replication. Thus, dominant lethals result from both chromatid- and chromosome-type aberrations while heritable translocations results primarily from the latter type. It is inherent in our interpretation of the mechanism that the production of chromosome- and chromatid-type aberrations by a chemical mutagen are not necessarily mutually exclusive. 17 refs., 1 tab. (DT)

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5478700
• Report Number(s): CONF-8506137-6; ON: DE85014309
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARBONIC ACID DERIVATIVES
DNA ADDUCTS
DNA REPAIR
DOMINANT MUTATIONS
EMS
EPOXIDES
ESTERS
FERTILIZATION
GAMETES
GERM CELLS
LETHAL MUTATIONS
METHYL NITROSOUREA
MUTAGENS
MUTATIONS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RECOVERY
REPAIR
SPERMATOGONIA
SULFONIC ACID ESTERS