Effects of dietary casein and soy protein on metabolism of radiolabelled low density apolipoprotein B in rabbits

Journal Article · Wed Mar 01 04:00:00 EST 1989 · Lipids; (USA)

DOI:https://doi.org/10.1007/BF02535230· OSTI ID:5477579

Samman, S; Khosla, P; Carroll, K K ^[1]

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1. Univ. of Western Ontario, London (Canada)

Rabbits fed semipurified diets containing casein have elevated plasma cholesterol levels compared to those fed soy protein. As part of continuing studies on the mechanism of casein-induced hypercholesterolemia, two groups of six rabbits were fed these diets for 14 to 16 weeks. Animals fed the casein diet were found to have significantly higher plasma concentrations of protein, cholesterol, triacylglycerol, phospholipid and apolipoprotein B (apo B) associated with low density lipoprotein (LDL) than those fed the soy protein diet. Kinetic studies showed that the fractional catabolic rate of LDL-apo B was significantly lower in animals fed casein than in those fed soy protein regardless of whether the tracer LDL was obtained from donors fed casein or soy protein. The production rate of LDL-apo B was higher in casein-fed animals but this was not statistically significant. These results show that the efficiency of removal of LDL is significantly reduced in animals fed casein compared to those fed soy protein, and that the source of LDL did not affect the efficiency of its subsequent removal. The accumulation of LDL in casein-fed animals is consistent with down-regulation of the LDL receptor.

• OSTI ID: 5477579
• Journal Information: Lipids; (USA), Journal Name: Lipids; (USA) Vol. 24:3; ISSN LPDSA; ISSN 0024-4201
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
APOLIPOPROTEINS
BIOLOGICAL EFFECTS
CASEIN
CHOLESTEROL
COMPARATIVE EVALUATIONS
DIET
ESTERS
HYDROXY COMPOUNDS
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIPIDS
LIPOPROTEINS
MAMMALS
MEMBRANE PROTEINS
METABOLISM
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PROTEINS
RABBITS
RECEPTORS
STEROIDS
STEROLS
TRACER TECHNIQUES
TRIGLYCERIDES
VERTEBRATES