Imipramine treatment differentially affects platelet /sup 3/H-imipramine binding and serotonin uptake in depressed patients

Journal Article · Mon Feb 25 00:00:00 EST 1985 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(85)90201-2· OSTI ID:5476786

Suranyi-Cadotte, B E; Quirion, R; Nair, N P.V.; Lafaille, F; Schwartz, G

Uptake of serotonin and /sup 3/H-imipramine binding in platelets of depressed patients were investigated simultaneously with changes in clinical state. Both V/sub max/ for serotonin uptake and B/sub max/ for /sup 3/H-imipramine binding were significantly lower in unmedicated depressed patients with respect to normal subjects. Successful treatment with imipramine led to a significant increase in B/sub max/ for /sup 3/H-imipramine binding, without significant change in V/sub max/ for serotonin uptake. B/sub max/ values increased to the normal range following complete, rather than partial clinical improvement. These data indicate that successful antidepressant treatment may increase the density of /sup 3/H-imipramine binding sites on platelets by a process which is independent of the uptake of serotonin. 29 references, 1 table.

• Research Organization: Douglas Hospital Research Centre, Verdun, France
• OSTI ID: 5476786
• Journal Information: Life Sci.; (United States), Vol. 36:8
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
IMIPRAMINE
CHEMICAL BONDS
SEROTONIN
UPTAKE
BLOOD PLATELETS
PATIENTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AMINES
ANTIDEPRESSANTS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MATERIALS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PSYCHOTROPIC DRUGS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
SYMPATHOMIMETICS
TRYPTAMINES
550201* - Biochemistry- Tracer Techniques