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Mutagenicity of airborne particles from a nonindustrial town

Journal Article · · Environ. Mutagen.; (United States)
; ; ; ; ;

The mutagenic activity of ambient air particles from Morgantown, West Virginia, has been monitored for 6 months using the Ames Salmonella assay system. Airborne particles, collected on glass fiber filters using a Hi-Vol sampler, were extracted with dichloromethane (DCM) and/or ethyl acetate plus methanol (E + M) in sequence. A dose-dependent mutagenic response was observed in Salmonella typhimurium TA 98 for DCM extracts from all samples. E + M extracts were mutagenic only when samples were extracted with E + M before DCM extration. The mutagenic activity of samples collected in June and July was independent of S-9 in vitro activation, whereas the mutagenicity of those collected from October to December increased in the presence of S-9 activation. The class fractionation of extracts showed that only acidic and polynuclear aromatic fractions were mutagenic. The mutagenicity of particles from Morgantown air was also detected with the Salmonella arabinose-resistant assay system.

Research Organization:
National Inst. for Occupational Safety and Health, Morgantown, WV
OSTI ID:
5473907
Journal Information:
Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 3:6; ISSN ENMUD
Country of Publication:
United States
Language:
English

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Related Subjects

500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
AROMATICS
BACTERIA
DOSE-RESPONSE RELATIONSHIPS
FEDERAL REGION III
GASEOUS WASTES
HYDROCARBONS
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENESIS
NORTH AMERICA
ORGANIC COMPOUNDS
PARTICLES
PARTICULATES
POLLUTION
POLYCYCLIC AROMATIC HYDROCARBONS
POWER PLANTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SAMPLING
SCREENING
SEASONAL VARIATIONS
USA
VARIATIONS
WASTES
WEST VIRGINIA