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Bioavailability of lead in rats fed human diets

Journal Article · · Bull. Environ. Contam. Toxicol.; (United States)
DOI:https://doi.org/10.1007/BF01685428· OSTI ID:5472994
;
The bioavailability of lead was studied in rats fed various baby foods (Babymix-turkey, Babymix-vegetables, Frutolino-fruit, Frutamix-bananas, Babyron-S-26, Truefood), cow's milk, bread, liver and standard rat diet. Lead absorption was determined by measuring the whole body retention of /sup 203/Pb 6 days after a single oral application. Highest absorption values ranging from 17 to 20% were obtained in animals fed cow's milk and fruit foods. Rats on other human diets absorbed between 3 and 8% of the radioactive lead dose. Only in animals on rat diet lead absorption was below 1%. It is concluded that rats fed human diets show absorption values similar to those in humans. This might indicate that the bioavailability of lead is primarily dependent on dietary habits. This experimental model, if confirmed by further work, might be useful for obtaining preliminary data on the bioavailability of metals from various foods.
Research Organization:
Inst. for Medical Research and Occupational Health, Zagreb, Yugoslavia
OSTI ID:
5472994
Journal Information:
Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 21:3; ISSN BECTA
Country of Publication:
United States
Language:
English

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Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIET
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
HEAVY NUCLEI
INTESTINAL ABSORPTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LEAD
LEAD 203
LEAD ISOTOPES
MAMMALS
MAN
METABOLISM
METALS
NUCLEI
PRIMATES
RADIOISOTOPES
RATS
RETENTION
RODENTS
SECONDS LIVING RADIOISOTOPES
TOLERANCE
TOXICITY
TRACER TECHNIQUES
UPTAKE
VERTEBRATES