Does hyperketonemia affect protein or glucose kinetics in postabsorptive or traumatized man
Journal Article
·
· Journal of Surgical Research; (USA)
- John Radcliffe Hospital, Oxford (England)
Leucine and glucose turnover were measured using simultaneous infusions of (13C)leucine and (2H)glucose before and during an infusion of Na DL-hydroxybutyrate (Na DL-HB) in overnight-fasted patients the day before and 3 days after total hip replacement. The ketone body infusion before surgery resulted in a significant increase in plasma leucine concentration and leucine turnover, while glucose concentration and turnover decreased. Surgery increased leucine turnover. Ketone body infusion after surgery caused a further increased leucine turnover while turnover fell as before surgery. We suggest that exogenous ketone bodies decrease hepatic glucose production and probably stimulate a rise in protein synthesis above breakdown leading to a decreased nitrogen excretion as observed by other investigators. Despite the metabolic adaptation to trauma, this response was not affected by surgery.
- OSTI ID:
- 5471331
- Journal Information:
- Journal of Surgical Research; (USA), Journal Name: Journal of Surgical Research; (USA) Vol. 47:4; ISSN 0022-4804; ISSN JSGRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
550600 -- Medicine
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
AMINO ACIDS
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
BODY
BODY AREAS
CARBOHYDRATES
CARBON 13
CARBON ISOTOPES
CARBOXYLIC ACIDS
DEUTERIUM
EVEN-ODD NUCLEI
FASTING
GLUCOSE
HEXOSES
HORMONES
HYDROGEN ISOTOPES
INJURIES
INSULIN
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
LEUCINE
LIGHT NUCLEI
MEDICAL SUPPLIES
MEDICINE
METABOLISM
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
PELVIS
PEPTIDE HORMONES
PROSTHESES
SACCHARIDES
STABLE ISOTOPES
SURGERY
TRACER TECHNIQUES
WOUNDS
550600 -- Medicine
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
AMINO ACIDS
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
BODY
BODY AREAS
CARBOHYDRATES
CARBON 13
CARBON ISOTOPES
CARBOXYLIC ACIDS
DEUTERIUM
EVEN-ODD NUCLEI
FASTING
GLUCOSE
HEXOSES
HORMONES
HYDROGEN ISOTOPES
INJURIES
INSULIN
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
LEUCINE
LIGHT NUCLEI
MEDICAL SUPPLIES
MEDICINE
METABOLISM
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
PELVIS
PEPTIDE HORMONES
PROSTHESES
SACCHARIDES
STABLE ISOTOPES
SURGERY
TRACER TECHNIQUES
WOUNDS