Use of thallium-201 SPECT to quantitate malignancy grade of gliomas

Journal Article · Fri Sep 01 00:00:00 EDT 1989 · Journal of Neurosurgery; (USA)

DOI:https://doi.org/10.3171/jns.1989.71.3.0342· OSTI ID:5470866

Black, K L; Hawkins, R A; Kim, K T; Becker, D P; Lerner, C; Marciano, D ^[1]

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1. Univ. of California, Los Angeles (USA)

A quantitative preoperative technique using thallium-201 single-photon emission computerized tomography is described which predicts whether specific gliomas are of high- or low-grade malignancy. An index, based on the ratio of thallium uptake in the tumor versus the homologous contralateral brain, was calculated and compared with tumor histology. The index in 14 patients with low-grade malignant gliomas was 1.27 {plus minus} 0.40 in contrast to an index of 2.40 {plus minus} 0.61 in 11 patients with high-grade malignant gliomas (p less than 0.0005). Whether gliomas were of low- or high-grade malignancy could be predicted with 89% accuracy using a threshold of 1.5. Low-grade gliomas with an index higher than 1.5 acted biologically more like high-grade tumors, and no tumor histologically classified as being of high-grade malignancy had an index lower than 1.7. This technique could help to reduce unrecognized sampling errors during needle biopsies of brain tumors, particularly of high-grade lesions classified in error as low-grade tumors due to inadequate biopsy material.

• OSTI ID: 5470866
• Journal Information: Journal of Neurosurgery; (USA), Journal Name: Journal of Neurosurgery; (USA) Vol. 71:3; ISSN 0022-3085; ISSN JONSA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
GLIOMAS
HEAVY NUCLEI
HEMORRHAGE
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SYMPTOMS
THALLIUM 201
THALLIUM ISOTOPES
TOMOGRAPHY