Recirculation subtraction for analysis of left-to-right-cardiac shunts: concise communication

Journal Article · Tue Dec 01 04:00:00 EST 1981 · J. Nucl. Med.; (United States)

OSTI ID:5464336

Houser, T S; MacIntyre, W J; Cook, S A; Go, R T; Moodie, D S; Ceimo, J; Gallagher, J H

The object of this study is to improve the techniques for describing the lung dilution curve for shunt quantification by separating the effects of systemic recirculation on the curve from those of direct shunt return. The time of the systemic recirculation peak was estimated by determination of transit times from the right and left ventricles and lung. A gamma variate fit based on the distribution of points at that segment was applied to the recirculation curve and subtracted from the original lung dilution curve. Similar gamma variate fitting was performed for both primary and shunt curves. Rather than fitting the gamma variate of the shunt curve by the leading edge only, a larger portion could now be used since the trailing edge of the curve is clearer following recirculation subtraction. The algorithm is completely automatic, requiring no operator intervention or selection of curve-fitting regions. The correlation coefficient for comparison of the dilution-curve analysis with oximetry determinations was 0.92 in a series of 29 patients.

• Research Organization: Cleveland Clinic Foundation, Ohio
• OSTI ID: 5464336
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:12; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALGORITHMS
BLOOD CIRCULATION
BLOOD FLOW
BODY
CALCULATION METHODS
CARDIOVASCULAR SYSTEM
CORRELATIONS
ELEMENTS
HEART
LUNGS
MATHEMATICAL LOGIC
MATHEMATICAL MODELS
METALS
ORGANS
PATIENTS
RESPIRATORY SYSTEM
STATISTICAL MODELS
TECHNETIUM
TRANSITION ELEMENTS