Survival of penicillamine-treated mice following whole-body irradiation

Journal Article · Tue Jan 01 00:00:00 EST 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575367· OSTI ID:5463204

Ward, W F; Shih-Hoellwarth, A; Johnson, P M

D-penicillamine (..beta..,..beta..-dimetnylcysteine) protected male mice against whole-body radiation lethality when the drug was injected (ip) before but not after irradiation. The LD/sub 50/30/ of control mice was 679 +- 28 rad, compared to values of 709 +- 25, 766 +- 28, and 808 +- 36 rad for animals given 10 or 100 mg penicillamine or 40 mg L-cysteine, respectively, 15 min before whole-body exposure to 500 to 1000 rad of /sup 60/Co-..gamma.. rays. Dose reduction factors were 1.04 +- 0.04 and 1.13 +- 0.04 for low and high doses of penicillamine and 1.19 +- 0.05 for cysteine.

• Research Organization: Northwestern Univ., Chicago, IL
• OSTI ID: 5463204
• Journal Information: Radiat. Res.; (United States), Vol. 81:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COBALT 60
BIOLOGICAL RADIATION EFFECTS
GAMMA RADIATION
PENICILLAMINE
RADIOSENSITIVITY EFFECTS
WHOLE-BODY IRRADIATION
DOSE-RESPONSE RELATIONSHIPS
DOSES
EXPERIMENTAL DATA
ISOLATED VALUES
LETHAL RADIATION DOSE
MALES
MICE
MORTALITY
SURVIVAL TIME
TIME DEPENDENCE
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CHELATING AGENTS
COBALT ISOTOPES
DATA
DATA FORMS
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LETHAL DOSES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
RODENTS
THIOLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals