Whole-thorax radiation lethality in penicillamine-treated mice. [/sup 60/Co]

Journal Article · Fri Jan 01 00:00:00 EST 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575709· OSTI ID:5207481

Ward, W F; Shih-Hoellwarth, A; Pearlman, H G; Kepka, A G

A total of 451 male mice received a single exposure of 0-20 Gy of /sup 60/Co ..gamma.. rays to the whole thorax. Half the animals consumed control diet, and half consumed diet supplemented with the collagen antagonist D-penicllamine (2 mg/day, po). Survival was observed daily, and body weight was recorded biweekly for 1 year after irradiation. The LD /sub 50;60-180 days/ of untreated and penicillamine-treated mice was 15.9 +/- 0.7 and 16.5 +/- 0.9 Gy, respectively, yielding a drug DRF of 1.04 (P > 0.05). In contrast, LD/sub 50;181-360 days/ of the two groups was 12.0 +/- 1.3 and 14.4 +/- 0.9 Gy, respectively, yielding a penicillamine DRF of 1.20 (P < 0.05). Thus it appears that penicillamine is ineffective against fatal radiation pneumonitis but significantly reduces mortality resulting from radiation-induced pulmonary fibrosis in mice irradiated to the whole thorax. While penicillamine did not reduce the incidence of early (<6 months) lung deaths, drug-treated mice weighed significantly (P < 0.05) more than their untreated counterparts during that time.

• Research Organization: Northwestern Univ. Medical School, Chicago, IL
• OSTI ID: 5207481
• Journal Information: Radiat. Res.; (United States), Vol. 90:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FIBROSIS
RADIOINDUCTION
LUNGS
DELAYED RADIATION EFFECTS
PENICILLAMINE
RADIOSENSITIVITY EFFECTS
PNEUMONITIS
CHEST
COBALT 60
GAMMA RADIATION
LETHAL RADIATION DOSE
MICE
PARTIAL BODY IRRADIATION
SURVIVAL TIME
WEIGHT
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARBOXYLIC ACIDS
CHELATING AGENTS
COBALT ISOTOPES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LETHAL DOSES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RODENTS
THIOLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals