Hepatic copper content in normal and toxic milk neonatal mice
Conference
·
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5461746
Adult toxic milk mice exhibit over ten times normal amounts of hepatic copper. Patterns of hepatic copper accumulation were followed in neonates born both to normal (+/-/+/-, +/-/tx/-) and mutant (tx/-/tx/-) mothers. At birth all offspring of normal dams have high hepatic copper levels which then decline over the next two weeks; after this time levels in normal neonates continue to decline while in mutant neonates levels rise sharply, both genotypes attaining adult levels by six weeks. Conversely, all offspring of mutant females are born severely copper deficient, a condition exacerbated by ingestion of the copper deficient milk that these females produce, which leads to death during the second week. Such infants can be rescued if fostered to normal lactating females at birth; copper levels rise for two weeks and then fall in normal infants but continue to rise in mutant infants. Beginning at the third postnatal week then, hepatic copper levels are attributable to infant genotype, while prior to this time concentrations reflect maternal genotype. The pattern of uptake of /sup 67/Cu by neonates is consistent with the copper content observed above. Those hepatic cuproproteins which vary according to genotype also indicate that the third week is the time when infant genotype becomes expressed in phenotype. The significant accumulation of copper in the livers of fetuses carried by normal dams is compared to that occurring in the livers of suckling mutants.
- Research Organization:
- Univ. of Massachusetts, Amherst
- OSTI ID:
- 5461746
- Report Number(s):
- CONF-8604222-
- Conference Information:
- Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
COPPER
COPPER 67
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELEMENTS
FETUSES
FOOD
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MAMMALS
MATERIALS
METABOLISM
METALS
MICE
MILK
MUTANTS
NEONATES
NUCLEI
NUTRITIONAL DEFICIENCY
ODD-EVEN NUCLEI
ORGANS
PHENOTYPE
PROGENY
RADIOISOTOPES
RODENTS
TRACER TECHNIQUES
TRANSITION ELEMENTS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
COPPER
COPPER 67
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELEMENTS
FETUSES
FOOD
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MAMMALS
MATERIALS
METABOLISM
METALS
MICE
MILK
MUTANTS
NEONATES
NUCLEI
NUTRITIONAL DEFICIENCY
ODD-EVEN NUCLEI
ORGANS
PHENOTYPE
PROGENY
RADIOISOTOPES
RODENTS
TRACER TECHNIQUES
TRANSITION ELEMENTS
VERTEBRATES