Pneumoconiosis in Rats Exposed Chronically to Oil Shale Dust and Diesel Exhaust, Alone and in Combination
Conference
·
· The Annals of Occupational Hygiene
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research
Rats were exposed by chronic inhalation to diesel exhaust or oil shale dust, alone and in combination to examine pathophysiologic interactions between the dusts. The three agents all accumulated progressively in lungs and caused similar pneumoconiotic responses. The effects of combined exposures tended to be greater than additive. The magnitude of effects was more closely correlated to particle lung burden than to exposure concentration. This suggests that effects of prolonged human exposures to combined dust atmospheres may be estimated better on the basis of predicted lung burden than exposure concentration.
- Research Organization:
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
- Sponsoring Organization:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- DOE Contract Number:
- AC04-76EV01013
- OSTI ID:
- 5458483
- Report Number(s):
- CONF-9109241--6; ON: DE91017517
- Conference Information:
- Journal Name: The Annals of Occupational Hygiene Journal Volume: 38
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BODY BURDEN
CHRONIC EXPOSURE
CLEARANCE
COLLOIDS
DIESEL ENGINES
DISEASES
DISPERSIONS
ENGINES
EXCRETION
HEAT ENGINES
INHALATION
INTAKE
INTERNAL COMBUSTION ENGINES
ISOTOPE APPLICATIONS
LAVAGE
LUNG CLEARANCE
MAMMALS
MINING
OCCUPATIONAL EXPOSURE
OIL SHALE FINES
OIL SHALE MINING
PARTICLE SIZE
PNEUMOCONIOSES
RATS
RESIDUES
RESPIRATORY SYSTEM DISEASES
RISK ASSESSMENT
RODENTS
SIZE
SMOKES
SOLS
SYNERGISM
TOXICITY
TRACER TECHNIQUES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BODY BURDEN
CHRONIC EXPOSURE
CLEARANCE
COLLOIDS
DIESEL ENGINES
DISEASES
DISPERSIONS
ENGINES
EXCRETION
HEAT ENGINES
INHALATION
INTAKE
INTERNAL COMBUSTION ENGINES
ISOTOPE APPLICATIONS
LAVAGE
LUNG CLEARANCE
MAMMALS
MINING
OCCUPATIONAL EXPOSURE
OIL SHALE FINES
OIL SHALE MINING
PARTICLE SIZE
PNEUMOCONIOSES
RATS
RESIDUES
RESPIRATORY SYSTEM DISEASES
RISK ASSESSMENT
RODENTS
SIZE
SMOKES
SOLS
SYNERGISM
TOXICITY
TRACER TECHNIQUES
VERTEBRATES