Bone tumors in Thorotrast patients. [Ra]

Journal Article · Thu Feb 01 04:00:00 EST 1979 · Environ. Res.; (United States)

OSTI ID:5457182

Mays, C W ^[1]; Spiess, H

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1. Univ. of Utah, Salt Lake City

Among the Thorotrast patients throughout the world, nine bone sarcomas (six histologically confirmed and three possible) were reported as of 1974. Their appearance times ranged from 16 to 33 years, averaging 26 years after Thorotrast injection. In some countries the population at risk is uncertain, but in Denmark, Germany, and Portugal, about 3000 patients have been followed more than 10 years (45,000 persons - years at risk beyond the first 10 years). In these 3000 patients, three to six bone sarcomas have occurred, compared with 0.5 case expected naturally. Using the dosimetric results of Rowland and Rundo and assuming the translocating /sup 224/Ra was mainly responsible, the provisional risk coefficient is 55 to 120 bone sarcomas/10/sup 6/ person - rad of actual dose to the skeleton without marrow. This risk coefficient is highly tentative because it is based on only three to six bone sarcomas, all reported since 1972. If additional bone sarcomas occur among the living Thorotrast patients, the risk coefficient could increase appreciably. For comparison, the risk coefficient for long protracted injections of /sup 224/Ra is about 200 bone sarcomas/10/sup 6/ person - rad, based on 54 cases of bone sarcoma.

• DOE Contract Number: EY-76-C-02-0119
• OSTI ID: 5457182
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 18:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560171* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE TISSUES
CHALCOGENIDES
COLLOIDS
CONNECTIVE TISSUE
CONTRAST MEDIA
DAYS LIVING RADIOISOTOPES
DELAYED RADIATION EFFECTS
DISEASES
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
EVEN-EVEN NUCLEI
HEAVY NUCLEI
ISOTOPES
LATENCY PERIOD
MEDICAL SURVEILLANCE
NEOPLASMS
NUCLEI
OSTEOSARCOMAS
OXIDES
OXYGEN COMPOUNDS
PATIENTS
RADIATION EFFECTS
RADIOCOLLOIDS
RADIOINDUCTION
RADIOISOTOPES
RADIUM 224
RADIUM ISOTOPES
SARCOMAS
SKELETAL DISEASES
THORIUM COMPOUNDS
THORIUM OXIDES
THOROTRAST
TIME DEPENDENCE
TISSUES
TOXICITY