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Mononuclear cells in the corneal response to endotoxin

Journal Article · · Invest. Ophthalmol. Visual Sci.; (United States)
OSTI ID:5451603
; ;

A severe keratitis can be produced after the direct injection of bacterial endotoxin, or lipopolysaccharide (LPS), in rabbits. Corneal inflammation can progress to scarring and vascularization within a 2 to 3 week period. Pretreatment with systemic adrenal corticosteroids (triamcinolone) prevents this response. Limbal cellular and vascular events were studied during the first 20 hr after injection of LPS in treated and nontreated rabbits. Perivascular limbal inflammatory cells were counted and limbal vascular permeability was assessed by extravasation of 131I-albumin and 125I-fibrinogen in the cornea. Corticosteroids decreased but did not prevent the early protein extravasation and profoundly altered the inflammatory cell population around blood vessels at the limbus. Mononuclear cells, particularly mononuclear phagocytes, were sharply reduced. It is proposed that these cell types play an important role in the perpetuation and amplification of the inflammatory response in this reaction.

Research Organization:
Department of Pathology, University of Calfornia Medical School, San Francisco
OSTI ID:
5451603
Journal Information:
Invest. Ophthalmol. Visual Sci.; (United States), Journal Name: Invest. Ophthalmol. Visual Sci.; (United States) Vol. 22:4; ISSN IOVSD
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
550701 -- Microbiology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ANIMALS
ANTIGENS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BODY
BODY AREAS
CARBOHYDRATES
CHEMISTRY
CORNEA
CORTICOSTEROIDS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ENDOTOXINS
ESCHERICHIA COLI
EYES
FACE
HEAD
HORMONES
HYDROXY COMPOUNDS
INFECTIVITY
INFLAMMATION
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE 131
IODINE ISOTOPES
ISOTOPES
KETONES
LIPIDS
LIPOPOLYSACCHARIDES
MAMMALS
MATERIALS
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PERMEABILITY
POLYSACCHARIDES
PREGNANES
RABBITS
RADIOISOTOPES
SACCHARIDES
SENSE ORGANS
STEROID HORMONES
STEROIDS
SYMPTOMS
TOXIC MATERIALS
TOXINS
VERTEBRATES