Acute effect of prostaglandins and somatostatin on thymidine uptake of gastric mucosa cells

Journal Article · Thu Dec 01 04:00:00 EST 1988 · Experimental Cell Research; (United States)

DOI:https://doi.org/10.1016/0014-4827(88)90278-9· OSTI ID:5450911

Alino, S F; Hilario, E ^[1]

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1. Univ. of Pais Vasco, Vizcaya (Spain)

This study compares the in vivo effect of exogenous administration of prostaglandin E2 (30 {mu}g/kg) and its precursor, arachidonic acid (30 {mu}g/kg), with the effect of indomethacin (5 mg/kg) on the 6-({sup 3}H)thymidine uptake of antral mucosa of mice by autoradiographical methods. Likewise, the effect of somatostatin (30 {mu}g/kg) on 6-({sup 3}H)thymidine uptake is studied. Evaluation of the number of labeled cells, in the histological sections of the gastric mucosa, showed that arachidonic acid, prostaglandin E2, and somatostatin induced an increase in the number of labeled cells (107, 44, and 45%, respectively), while indomethacin induced a decrease of 32% compared to the control group. These results suggest that prostaglandins may mediate stimulatory effects on thymidine uptake of gastric mucosa cells in the first step after drug administration.

• OSTI ID: 5450911
• Journal Information: Experimental Cell Research; (United States), Journal Name: Experimental Cell Research; (United States) Vol. 179:2; ISSN ECREA; ISSN 0014-4827
• Country of Publication: United States
• Language: English

Related Subjects

550301* -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
ARACHIDONIC ACID
AUTORADIOGRAPHY
AZINES
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
EPITHELIUM
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
MAMMALS
MEMBRANES
MICE
MONOCARBOXYLIC ACIDS
MUCOUS MEMBRANES
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROSTAGLANDINS
PYRIMIDINES
RIBOSIDES
RODENTS
SOMATOSTATIN
STOMACH
THYMIDINE
TISSUES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES