Accuracy of diagnosis of coronary artery disease by radionuclide management of left ventricular function during rest and exercise

Journal Article · Tue Sep 01 04:00:00 EDT 1981 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.64.3.586· OSTI ID:5450703

Jones, R H; McEwan, P; Newman, G E; Port, S; Rerych, S K; Scholz, P M; Upton, M T; Peter, C A; Austin, E H; Leong, K H; Gibbons, R J; Cobb, F R; Coleman, R E; Sabiston, Jr, D C

Rest and exercise radionuclide angiocardiographic measurements of left ventricular function were obtained in 496 patients who underwent cardiac catheterization for chest pain. Two hundred forty-eight of these patients also had an exercise treadmill test. An ejection fraction less than 50% was the abnormality of resting left ventricular function that provided the greatest diagnostic information. In patients with normal resting left ventricular function, exercise abnormalities that were optimal for diagnosis of coronary artery disease were an injection fraction at least 6% less than predicted, an increase greater than 20 ml in end-systolic volume and the appearance of an exercise-induced wall motion abnormality. The sensitivity and specificity of the test were lower in patients who were taking propranolol at the time of study and in patients who failed to achieve an adequate exercise end point. In the 387 patients with an optimal study, the test had a sensitivity of 90% and a specificity of 58%. Radionuclide angiocardiography was more sensitive and less specific than the exercise treadmill test. The high degree of sensitivity of the radionuclide test suggests that it is most appropriately applied to patient groups with a high prevalence of disease, including those considered for cardiac catheterization.

• OSTI ID: 5450703
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 64:3; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ARTERIES
BLOOD VESSELS
BODY
CARDIOGRAPHY
CARDIOVASCULAR SYSTEM
CORONARIES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DYNAMIC FUNCTION STUDIES
EXERCISE
HEART
ORGANS
PATHOLOGY
PATIENTS
RADIOCARDIOGRAPHY
SPECIFICITY
USES
VASCULAR DISEASES