Major alteration of the pathological phenotype in gamma irradiated mdx soleus muscles

Journal Article · Mon Jul 01 00:00:00 EDT 1991 · Journal of Neuropathology and Experimental Neurology; (United States)

DOI:https://doi.org/10.1097/00005072-199107000-00003· OSTI ID:5448383

Weller, B; Karpati, G; Lehnert, S; Carpenter, S ^[1]

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1. Montreal Neurological Institute, McGill University, Quebec (Canada)

Two thousand rads of gamma irradiation delivered to the lower legs of ten day old normal and x-chromosome linked muscular dystrophy (mdx) mice caused significant inhibition of tibial bone and soleus muscle fiber growth. In the irradiated mdx solei, there was a major loss of muscle fibers, lack of central nucleation, and some endomysial fibrosis. These features were caused by a failure of regeneration of muscle fibers due to impaired proliferative capacity of satellite cells. Gamma irradiation transforms the late pathological phenotype of mdx muscles, so that in one major aspect (muscle fiber loss) they resemble muscles in Duchenne muscular dystrophy. However, extensive endomysial fibrosis which is another characteristic feature of Duchenne muscular dystrophy did not develop. This experimental model could be useful for the functional investigation of possible beneficial effects of therapeutic interventions in mdx dystrophy.

• OSTI ID: 5448383
• Journal Information: Journal of Neuropathology and Experimental Neurology; (United States), Journal Name: Journal of Neuropathology and Experimental Neurology; (United States) Vol. 50:4; ISSN 0022-3069; ISSN JNENA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL GROWTH
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHROMOSOMES
DISEASES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GROWTH
HETEROCHROMOSOMES
INHIBITION
IONIZING RADIATIONS
MAMMALS
MEDICINE
MICE
MUSCLES
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ORGANS
PHENOTYPE
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RODENTS
SKELETON
THERAPY
TIBIA
VERTEBRATES
X CHROMOSOME